Aminobenzoic acids and derivatives
Selleck Chemical LLC Almitrine mesylate S4439-1g
Almitrine mesylate (Almitrine bismesylate Almitrine dimethanesulfonate Almitrine dimesylate) a pharmacologically unique respiratory stimulant acts as an agonist of peripheral chemoreceptors located on the carotid bodies Almitrine mesylate inhibits the activity of Ca2 -dependent K channel by decreasing its open probability with IC50 of 0 22 M
Selleck Chemical LLC Urolithin A S5312-10mM/1mL
Urolithin A (3 8-Dihydroxy Urolithin 2 7-Dihydroxy-3 4-benzocoumarin) a metabolite of ellagitannin is a first-in-class natural compound that induces mitophagy both in vitro and in vivo following oral consumption
Selleck Chemical LLC Pifithrin-a (PFTa) HBr S2929-1g
Pifithrin- is an inhibitor of p53 inhibiting p53-dependent transactivation of p53-responsive genes Pifithrin- is also a potent agonist of the aryl hydrocarbon receptor (AhR)
Medchemexpress LLC (R)-Leucic acid (D-α-Hydroxyisocaproic acid) | 20312-37-2 | 98.0% | 132.16 | 100 G
(R)-Leucic acid, also known as D-α-Hydroxyisocaproic acid, is an orally active D-isomer that functions as an α-hydroxy analogue of Leucine. This compound is a metabolite produced by Lactobacillus and has been shown to enhance intestinal fatty acid absorption through the upregulation of CD36 expression. It serves as a valuable tool for researchers investigating microbe-host interactions and the mechanisms by which probiotics influence lipid metabolism.
- Orally active D-isomer of Leucine's α-hydroxy analogue.
- Functions as a metabolite of Lactobacillus.
- Promotes intestinal fatty acid absorption via CD36 upregulation.
- Useful for studying microbe-host interactions.
- Applicable in research concerning the regulation of lipid metabolism by probiotics.
Medchemexpress LLC 4-(Dimethylamino)phenol | 619-60-3 | 99.75% | 137.18 | 5 G
4-(Dimethylamino)phenol is a potent cyanide antidote. It increases the extracellular lactate dehydrogenase (LDH) without markedly affecting gluconeogenesis. It cannot decrease the ATP content until the membrane becomes permeable to LDH. Its toxicity is related to its reaction with glutathione and formation of covalent complexes, leading to impaired cellular function.
- Potent cyanide antidote.
- Increases the extracellular lactate dehydrogenase (LDH).
Sigma Aldrich Fine Chemicals Biosciences Procainamide hydrochloride >=98% (HPLC) | 614-39-1 | MFCD00012998 | 1G
Procainamide hydrochloride >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 271.79 | 614-39-1 | MFCD00012998 | 1G
Medchemexpress LLC (R)-2-Amino-3-(2-fluorophenyl)propanoic acid | 97731-02-7 | 99.58% | 183.18 | 5 G
(R)-2-Amino-3-(2-fluorophenyl)propanoic acid is a phenylalanine derivative. Amino acids and amino acid derivatives are commercially used as ergogenic supplements, influencing the secretion of anabolic hormones, fuel supply during exercise, mental performance during stress-related tasks, and preventing exercise-induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances.
- Phenylalanine derivative
- Influences secretion of anabolic hormones
- Supplies fuel during exercise
- Enhances mental performance during stress-related tasks
- Prevents exercise-induced muscle damage
Cayman Chemical Latrunculin A Inhibitors
An actin disruption agent; sequesters G-actin and prevents F-actin assembly; binds monomeric actin with 1:1 stoichiometry and can be used to block actin polymerization both in vitro (Kd = 0.2 μM) and in cells (0.5 μM, 30 min); causes depolymerization of tumor cell cytoskeleton within ten minutes at 1-10 μM; suppresses actin synthesis at 10 μM; blocks dexamethasone-induced changes in actin cytoskeleton
Cayman Chemical WIN 55 212 mesylate
A racemic mixture of (+)-WIN 55,212-2 and (−)-WIN 55,212-3; inhibits electrically induced contractions in mouse vas deferens preparations (IC50 = 0.006 µM) and reduces PG synthesis by 35% in mouse brain microsomes at 30 µM; decreases acetylcholine-induced writhing in mice (ED50 = 0.25 mg/kg); induces hypolocomotion, analgesia, hypothermia, and catalepsy in mice (ED50s = 1.09, 0.5, 3.01 and 6.8 mg/kg, respectively)
Cayman Chemical Manumycin A Inhibitors
A potent and selective farnesyltransferase (FTase) inhibitor with anti-tumor activity: inhibits rat brain FTase with a Ki value of 1.2 µM, thereby preventing Ras activation; inhibits IKK in an number of cells types
Aobchem 2 6-Dibromo-4-methylbenzoic acid | ≥97% | CAS 128733-74-4 | C8H6Br2O2 | 250mg
2 6-Dibromo-4-methylbenzoic acid | ≥97% | CAS 128733-74-4 | C8H6Br2O2 | 250mg
Medchemexpress LLC Succinyl-Coenzyme A sodium | 108347-97-3 | ≥99.0% | 1 MG
Succinyl-Coenzyme A sodium is a pivotal intermediate metabolite in the tricarboxylic acid cycle and a key coenzyme A metabolite. It is biosynthesized from α-ketoglutarate or propionyl-CoA. Succinyl-Coenzyme A sodium acts as a critical precursor and substrate for heme biosynthesis and gluconeogenesis. Insufficiency of Succinyl-Coenzyme A sodium caused by cobalamin deficiency is directly linked to growth retardation, impaired heme synthesis, tissue glycine accumulation, and neurological abnormalities.
- It can be used in research on metabolic, neurological, and hematological abnormalities (such as porphyria) caused by nutritional vitamin B12 deficiency (leading to a lack of Succinyl-Coenzyme A synthesis).
- It acts as a substrate for rat liver δ-aminolevulinic acid synthase-1 with a Michaelis constant (Km) of 6-120 μmol/L.
- It does not bind to recombinant NLRX1 in an in vitro pull-down assay.
TARGETMOL CHEMICALS INC RG108 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. RG108 (N-Phthalyl-L-tryptophan) is an DNA methyltransferase inhibitor(IC50=115 nM). purity: 99%
TARGETMOL CHEMICALS INC WITHAFERIN A 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. WITHAFERIN A is a novel class of NFkappaB inhibitors which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/or cancer. purity: 99%